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Scientist (f/m) / PhD position
Category:
Phd

Description:
We are looking for highly talented PhD students who are interested in using a highly flexible and versatile model organism to explore the principles underlying cellular dynamics and organization. We combine a broad range of methods, from low to high throughput microscopy, genomics, genetic and genomic screening to biochemical assays and cell biological approaches to explore how cells regulate protein homeostasis, how they deal with disturbances that can affect the processes of gene expression and protein production, and how they optimize their responses.

References:

Huber F, Bunina D, Gupta I, Khmelinskii A, Meurer M, Theer P, Steinmetz LM & Knop M (2016) Protein Abundance Control by Non-coding Antisense Transcription. Cell Rep 15: 2625–2636

Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G, Ljungdahl PO & Knop M (2014) Protein quality control at the inner nuclear membrane. Nature 516: 410–413

Meitinger F, Khmelinskii A, Morlot S, Kurtulmus B, Palani S, Andres-Pons A, Hub B, Knop M, Charvin G & Pereira G (2014) A memory system of negative polarity cues prevents replicative aging. Cell 159: 1056–1069

Theer P, Dragneva D & Knop M (2016) πSPIM: high NA high resolution isotropic light-sheet imaging in cell culture dishes. Scientific Reports

Yofe I, Weill U, Meurer M, Chuartzman S, Zalckvar E, Goldman O, Ben-Dor S, Schütze C, Wiedemann N, Knop M, Khmelinskii A & Schuldiner M (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13: 371–378

Gibeaux R, Politi AZ, Nédélec F, Antony C & Knop M (2013) Spindle pole body-anchored Kar3 drives the nucleus along microtubules from another nucleus in preparation for nuclear fusion during yeast karyogamy. Genes Dev. 27: 335–349

 

 

Guan Y, Meurer M, Raghavan S, Rebane A, Lindquist JR, Santos S, Kats I, Davidson MW, Mazitschek R, Hughes TE, Drobizhev M, Knop M & Shah JV (2015) Live-cell multiphoton fluorescence correlation spectroscopy with an improved large Stokes shift fluorescent protein. Mol. Biol. Cell 26: 2054–2066

Capoulade J, Wachsmuth M, Hufnagel L & Knop M (2011) Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Nat. Biotechnol. 29: 835–839

Khmelinskii A, Keller PJ, Bartosik A, Meurer M, Barry JD, Mardin BR, Kaufmann A, Trautmann S, Wachsmuth M, Pereira G, Huber W, Schiebel E & Knop M (2012) Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Nat. Biotechnol. 30: 708–714

Methods that will be used:

We use a broad range of methods and expect students to have a good fundament in biology, a strong interest (and talent) in more technical directions, and to be eager to learn new methods and technologies to explore the fundamental principles of life.

Cooperation partners:

We are collaborating locally, nationally and internationally, and we expect that applicants are open to travel and exchange with collaboration partners.

Personal qualifications:

Successful applicants should be highly motivated to conduct challenging, original and internationally competitive research at the interface of cell and systems biology.

 

Deadline: 31. May 2017

 

Contact details: Knop, Michael