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PhD Position in Developmental Biology
Category:
Phd

Description:

We seek an outstanding PhD student in the context of the Research Consortium “CONNECT – Connecting Cancer Variants to Functions in Cellular Networks”. This consortium aims at a comprehensive association of so-far uncharacterized genetic events with structural alterations in human tumors, with the ultimate goal to translate basic science discoveries into targeted cancer therapies. To validate and characterize functional genetic co-dependencies, highly promising candidates will be selected to interfere with their individual and combined activity in a complex organismal setting. Due to availability of an extensive genetic and molecular toolbox, the Lohmann lab uses the fruit fly Drosophila melanogaster and will characterize approved interactions in the developing and adult eye, a well-established system for tumor studies. Studies include, but are not limited to, (i) global and clonal interference with selected candidate genes in the Drosophila eye in single and combined loss-of-function, hypomorphic or gain-of-function conditions and characterization of changes in cell behavior, most importantly cell survival, cell identity, cell polarity, proliferation and cell migration as well as invasion into ectopic tissues; and (ii) detailed analysis of mutation-specific functions identified using organism-wide gene replacement and tissue-specific overexpression strategies by engineering genetic alterations using CRISPR/Cas9 technology.

Your Profile: The successful candidate is a highly motivated, ambitious, hard-working individual with excellent grades who enjoys working in an international team and is passionate about making a difference through cancer research. Applicants should hold a master degree in biology, biochemistry, biotechnology, or a related field. The ideal candidate has expertise in molecular and cellular biology, with specific focus on the techniques described above, knowledge of the Drosophila model system is not expected but would be highly appreciated. Furthermore, the successful candidate is highly self-motivated, and able to pursue research projects independently. Excellent communication skills and proficiency in English are mandatory. Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications, and 2-3 references. You will join the research group of Prof. Ingrid Lohmann, which is part of the Centre for Organismal Studies (COS) at the University of Heidelberg, Germany and aims at a comprehensive understanding of Hox gene function in the Drosophila feeding motor unit. The position is immediately available, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered.

 

Contact details: Applications should be sent to:

Prof. Ingrid Lohmann

Heidelberg University

Centre for Organismal Studies (COS) Heidelberg

Department of Developmental Biology

Im Neuenheimer Feld 230 D-69120 Heidelberg Germany

Phone: +49 (0)6221 545523

Fax: +49 (0)6221 546424

Email: ingrid.lohmann [ aT ] cos.uni-heidelberg.de