PhD position: Microtubule assembly – a universal toolbox for track building
Category:
Phd

Description:

Microtubules are highly dynamic polymers with essential functions in chromosome segregation in mitosis and meiosis, intracellular organization, cell motility and neurogenesis. Microtubule malfunction is associated with cancer, infertility and neurological diseases.

 

Cells have developed mechanisms for the assembly of microtubules from their building block, the alpha/beta-tubulin heterodimer. The activity of the basic assembly machinery, the gamma-tubulin ring complex, is modulated in time and space by a toolbox of accessory factors, for example microtubule polymerases. In this project we aim to understand when and where these co-factors come in place and how their functions are changed in cancer and adapted in specific cell types, for example neurons.

 

The PhD student will use biochemical approaches, super resolution microscopy (STED and SIM), cryo-electron microscopy, CRISPR/Cas9 technology for genomic knockins and knockouts and live cell imaging to study microtubule assembly.

 

Highly motivated PhD students with a background in cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research (http://www.cell.com/developmental-cell/meet-the-author/berati-cerikan). The PhD student will be a member of the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (http://www.hbigs.uni-heidelberg.de/).

 

The PhD position (TV- L E13 (part-time)) is funded for 3 years.

 

Please send applications to E. Schiebel (schiebel.elmar [ aT ] zmbh.uni-heidelberg.de) by 17 December 2018

 

Mailing address: Prof Elmar Schiebel, ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany

 

Please understand that received applications cannot be returned. In case of same aptitude, priority employment for handicapped people.

 

For literature on this topic, please follow this link to our website:

 

http://www.zmbh.uni-heidelberg.de/schiebel/open.html