Beyond the Transport Function of Import Receptors: What's All the FUS about?
2018
Authors: Mikhaleva S, Lemke EA
CellNetworks People: Lemke Edward
Journal: Cell. 2018 Apr 19;173(3):549-553. doi: 10.1016/j.cell.2018.04.002

Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.