Far-field nanoscopy with reversible chemical reactions
Authors: Schwering M, Kiel A, Kurz A, Lymperopoulos K, Sprödefeld A, Krämer R, Herten DP
CellNetworks People: Herten Dirk-Peter
Journal: Angew Chem Int Ed Engl. 2011 Mar 21;50(13):2940-5. doi: 10.1002/anie.201006013

Revolution in resolution: Abbe's resolution limit has been overcome in fluorescence microscopy by using light-driven processes to switch the emission of fluorophores on and off. Alternatively, chemical reactions can be used, for example the coordination of Cu2+ ions to a fluorescent probe for the stochastic switching between spectroscopic states.