The CellNetworks nCounter Core Facility has been established to provide access to one of the current state of the art expression profiling technologies for the Heidelberg University research community.
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The CellNetworks Deep Sequencing Core Facility is currently being established to provide access to Next Generation Sequencing technology for the Heidelberg University research community. It is supported by the Excellence Cluster ‘Cell Networks‘, Heidelberg Molecular Life Sciences (HMLS) and the Heidelberg Center for Organismal Studies (COS Heidelberg).
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The EMCF provides technical and scientific support for transmission EM and scanning EM to all members of the University of Heidelberg. It is supported by the cluster of excellence ‘CellNetworks’, Heidelberg Molecular Life Sciences (HMLS) and the medical faculty of the University of Heidelberg.
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Located in Bioquant, the major focus of the Nikon Imaging Center is to provide instrumentation for advanced light microscopic imaging with regularly up-dated equipment to researchers on campus.
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An RNAi Screening Facility for medium and large scale (e.g. genome-wide RNAi) screening has been established for the CellNetworks cluster in the BIOQUANT building, taking advantage of the expertise already acquired from the existing platform at the EMBL.
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One of the most effective techniques for determining protein structures is X-ray crystallography, which requires high quality mono-crystals of the protein. Obtaining such crystals is an empirical, labour intensive process and a crucial step on the way to structure determination. Therefore, the CellNetworks Cluster of Excellence and the Biochemistry Center (AG Prof. Sinning) have established the Protein Crystallization Platform, a core facility that sets up and monitors high-throughput crystallization trials on a nano-liter scale.
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State of the art high-resolution mass spectrometry allows the identification and quantification of metabolites, proteins and their post-translational modifications. In order to meet the growing MS demands of the members of the CellNetworks cluster concerning specification, resolution and throughput, two core facilities for protein mass spectrometry have been set up at the Heidelberg University Biochemistry Center (BZH) and the Zentrum für Molekulare Biologie Heidelberg (ZMBH). Mass spectrometry for analyses of metabolites is being established at the Centre for Organismal Studies Heidelberg (COS).
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High throughput (HTP) screening of small molecules is essential for the discovery of potential regulators of intra- and supracellular networks and of lead substances for pharmacological intervention. Identifying such compounds requires the availability of suitable assays for HTP screening, as well as a compound library and the infrastructure for robotic screening. DKFZ and EMBL have jointly established a Chemical Biology Core Facility and Heidelberg University joined as a third partner in support of the CellNetworks program.
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