Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
|Authors:||Oliveira AM, Hemstedt TJ, Bading H|
|CellNetworks People:||Bading Hilmar, Oliveira Ana M.M.|
|Journal:||Nat Neurosci. 2012 Jul 1;15(8):1111-3. doi: 10.1038/nn.3151|
Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.