Mechanisms of regulated unconventional protein secretion.
Authors: Nickel W, Rabouille C.
CellNetworks People: Nickel Walter
Journal: Nat Rev Mol Cell Biol. 2009 Feb;10(2):148-55.

Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)-Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing proteins have been shown to reach the cell surface by non-conventional transport pathways. The mechanisms and molecular components of unconventional protein secretion are beginning to emerge, including a role for caspase 1 and for the peripheral Golgi protein GRASP, which could function as a plasma membrane tether for membrane compartments during specific stages of development.