SUMOylation - a regulatory protein modification in health and disease
|Authors:||Flotho F, Melchior F|
|CellNetworks People:||Melchior Frauke|
|Journal:||Annu Rev Biochem. 2013;82:357-85. doi: 10.1146/annurev-biochem-061909-093311|
Posttranslational modification with Small Ubiquitin-related Modifier (SUMO) proteins has established itself as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins in pathways such as chromatin organization, transcription, DNA repair, macromolecular assembly and protein homeostasis, trafficking and signal transduction are subject to reversible sumoylation. It is hence not surprising that disease links are beginning to emerge and that interference with sumoylation is considered for intervention. Here we will summarize basic mechanisms and highlight recent developments in the physiology of sumoylation.