A self-organization framework for symmetry breaking in the mammalian embryo
Authors: Wennekamp S, Mesecke S, Nédélec F, Hiiragi T.
CellNetworks People: Nédélec François
Journal: Nat Rev Mol Cell Biol. 2013 Jul;14(7):454-61. doi: 10.1038/nrm3602.

The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. Recent experimental advances have revealed unexpected dynamics of and new complexity in this process. These findings can be integrated in a new unified framework that regards the early mammalian embryo as a self-organizing system.