Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
2012
Authors: Melzer S, Michael M, Caputi A, Eliava M, Fuchs EC, Whittington MA, Monyer H
CellNetworks People: Monyer Hannah
Journal: Science. 2012 Mar 23;335(6075):1506-10. doi: 10.1126/science.1217139

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.