Independent hypothalamic circuits for social and predator fear
2013
Authors: Silva BA, Mattucci C, Krzywkowski P, Murana E, Illarionova A, Grinevich V, Canteras NS, Ragozzino D, Gross CT
CellNetworks People: Grinevich Valery
Journal: Nat Neurosci. 2013 Nov 10. doi: 10.1038/nn.3573. [Epub ahead of print]

The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans.