Independent hypothalamic circuits for social and predator fear
|Authors:||Silva BA, Mattucci C, Krzywkowski P, Murana E, Illarionova A, Grinevich V, Canteras NS, Ragozzino D, Gross CT|
|CellNetworks People:||Grinevich Valery|
|Journal:||Nat Neurosci. 2013 Nov 10. doi: 10.1038/nn.3573. [Epub ahead of print]|
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans.