A: Protein Machines - Biogenesis, Interactions and Regulations
Research area coordinator: Melchior, Frauke
Research area vice coordinator: Brunner, Michael

Starting from the molecular building blocks, we ultimately aim at a time-resolved, three-dimensional picture of cellular networks and their spatio-temporal dynamics on multiple length and time scales.

We focus on core aspects of cellular functions:

1. biogenesis and quality control of molecular machines,
2. membrane translocation and modification of proteins,
3. generic transport machinery of the secretory pathway, and
4. global regulation cycles that determine the cellular state.

A major challenge of the research is to access and quantify the relevant structural and dynamic parameters of molecular machines and their interaction, and the integration of these data to form a coherent picture of cellular networks and their regulation.