Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins
|Authors:||Rahmouni S, Lindner A, Rechenmacher F, Neubauer S, Sobahi TR, Kessler H, Cavalcanti-Adam EA, Spatz JP|
|CellNetworks People:||Spatz Joachim|
|Journal:||Adv Mater. 2013 Nov 6;25(41):5869-74. doi: 10.1002/adma.201301338. Epub 2013 Aug 5|
Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.