Hippocampal synaptic plasticity, spatial memory and anxiety
Authors: Bannerman DM, Sprengel R, Sanderson DJ, McHugh SB, Rawlins JN, Monyer H, Seeburg PH
CellNetworks People: Monyer Hannah
Journal: Nat Rev Neurosci. 2014 Mar;15(3):181-92. doi: 10.1038/nrn3677

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.