Fine tuning of hepcidin expression by positive and negative regulators
|CellNetworks People:||Muckenthaler Martina|
|Journal:||Cell Metab. 2008 Jul;8(1):1-3.|
Hepcidin, the systemic regulator of iron homeostasis is activated by proteins responsible for hereditary hemochromatosis, bone morphogenetic proteins (BMPs), and inflammatory cytokines. Three recent publications now identify a novel hepcidin suppressor, the transmembrane serine protease TMPRSS6 (also known as matriptase-2), which is required to sense iron deficiency.