Unravelling Spinal Circuits of Pain and Mechanical Allodynia
2015
Authors: Gangadharan V, Kuner R
CellNetworks People: Kuner Rohini
Journal: Neuron. 2015 Aug 19;87(4):673-5. doi: 10.1016/j.neuron.2015.08.013

How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia.