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New way to isolate DNA- and RNA-protein complexes
Posted July 26 2018
EMBL researchers develop method that simplifies the isolation of DNA- and RNA- protein complexes

By interacting with nucleic acids (DNA and RNA), proteins create complexes that regulate cell behaviour. In order to understand how these complexes regulate cell function, they must be isolated from nucleic acids. Claudio Asencio, a researcher in the Hentze group, has developed a new method, called Complex Capture (2C), that simplifies the extraction of complexes by using silica-based extraction columns commonly used in labs to purify nucleic acids.

 

SOURCE ARTICLE

Asencio, C., et al. Silica-based solid phase extraction of crosslinked nucleic acid-bound proteins. Life Science Alliance, published on 18 June, 2018. DOI: 10.26508/lsa.201800088

 

This article by the EMBL Press office is available here.