Natural Sciences
Life Sciences
Scientific Computing
Life Science

Renata Pasqualini and Wadih Arap, Department of Internal Medicine, UNM Comprehensive Cancer Center, University of New Mexico, Albuquerque, USA

ZMBH, Seminar room 001, ground floor, Im Neuenheimer Feld 282

Claudio Joazeiro, ZMBH

You may know Dr. Arap from his previous work in the lab of Web Cavenee at the Ludwig Institute in San Diego, California, where he studied the role of p16(INK4a) in glioma. Dr. Pasqualini and Dr. Arap are at currently at the Rutgers NJMS, in New Jersey. She is Professor & Chief of the Division of Cancer Biology, Department of Radiation Oncology, and he is Professor & Chief of the Division of Hematology/Oncology at the Department of Medicine. Dr. Pasqualini and Dr. Arap are pioneers in the development of in vivo phage display. This functional screening approach allows one to identify peptides displayed on the bacteriophage surface that homes the latter to specific tissues (either diseased or healthy). Once identified, such peptides can be chemically coupled, e.g., to chemotherapeutic agents for selective tissue delivery, thereby minimizing undesirable side effects. The approach was first established in animal models and has already been applied to cancer patients. An additional exciting outcome of this work has been the identification of tissue-specific receptors for the phage-encoded peptides. As it turns out, such peptides often target receptors residing in the vasculature, and are thus referred to as "vascular ZIP codes". The systematic implementation of this strategy has been leading to a comprehensive map of vascular markers in each organ or tissue. See:

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