Natural Sciences
Life Sciences
Scientific Computing
Scientific Computing

Philip Kollmannsberger, Biozentrum, Würzburg University

BioQuant, Seminar Room 041, Im Neuenheimer Feld 267

U. Schwarz, CellNetworks Member; M. Hausmann

Abstract: We develop and apply computational methods for automated image and network analysis, aiming towards a quantitative understanding of multicellular interactions in tissues. Our approach includes for example segmentation of synaptic structures from electron microscopic images using deep learning, clustering of neuronal proteins from 3D super-resolution microscopy, and the analysis of network structure and cell-matrix dynamics in 3D tissue culture as well as in-vivo. Based on the quantitative information from such large-scale image data, we develop theoretical models and generate new hypotheses on the structure and function of complex biological networks on all scales.

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