Natural Sciences
Life Sciences
Scientific Computing
June 19 2019 / 11:00 AM

Life Science

Jürgen Wienands, Cellular and Molecular Immunology, Georg August University, Göttingen

DKFZ, Communication Center, Im Neuenheimer Feld 280

John Lindner, BioMed X

Outline of the talk The B cell antigen receptor (BCR) plays a key role for antibody-mediated humoral immune responses. The general BCR structure comprises a membrane-bound immunoglobulin molecule of any of the five known isotypes (i.e. IgM, IgD, IgG, IgA or IgE) in association with the canonical signaling components CD79a and CD79b. The group investigates the mechanics of proximal and distal BCR signaling events and what distinguishes primary activation of newly generated B cells from recall responses of memory B cells. The seminar will focus on the identification of intracellular BCR effector proteins and their mode of action as well as on BCR isotype-specific signal signatures promoting the recognition of antigens with heightened sensitivity and hence the vigorous responsiveness of memory B cells.

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